Long CAG repeats + PacBio
GenomeWeb covers our efforts to measure microsatellite instability using PacBio sequencing.
We are funded by the NIH/NINDS to repair disease-causing CAG repeats
Expanded CAG/CTG repeat tracts are the genetic basis for more than a dozen inherited neurological disorders including Huntington’s disease, myotonic dystrophy, and several spinocerebellar ataxias. Despite the multitude of pathologies underlying these disorders, they all share common etiology: the expansion of CAG/CTG repeats.
Tour the Lab
Our laboratories and offices are located within the Virginia Bioinformatics Institute at Virginia Tech. Learn more about our facilities and get travel directions to VBI.
Drosophila Genetic Reference Panel
The DGRP project is a collaborative effort led by Trudy Mackay (NCSU), Richard Gibbs (BCM-HGSC) and Stephen Richards (BCM-HGSC) to measure genotypes and phenotypes in a couple hundred inbred D. melanogaster lines derived from a phenotypically diverse natural population in Raleigh, North Carolina.
Measuring Genome Instability
Microsatellite repeats are mutational hotspots and their mutagenesis can be constitutively regulated by cis and trans modifiers; as well as induced by transcription and stress. We use repeats to characterize pathways that regulate genome maintenance.
New book “Stress-Induced Mutagenesis” now available!
Check out our new book on stress-induced mutagenesis and genomic instability. We are so grateful to the authors, all leaders in their respective fields, for contributing to this exciting new volume.