GenomeWeb covers our efforts to measure microsatellite instability using PacBio sequencing.
Expanded CAG/CTG repeat tracts are the genetic basis for more than a dozen inherited neurological disorders including Huntington’s disease, myotonic dystrophy, and several spinocerebellar ataxias. Despite the multitude of pathologies underlying these disorders, they all share common etiology: the expansion of CAG/CTG repeats.
Our laboratories and offices are located within the Virginia Bioinformatics Institute at Virginia Tech. Learn more about our facilities and get travel directions to VBI.
The DGRP project is a collaborative effort led by Trudy Mackay (NCSU), Richard Gibbs (BCM-HGSC) and Stephen Richards (BCM-HGSC) to measure genotypes and phenotypes in a couple hundred inbred D. melanogaster lines derived from a phenotypically diverse natural population in Raleigh, North Carolina.
Microsatellite repeats are mutational hotspots and their mutagenesis can be constitutively regulated by cis and trans modifiers; as well as induced by transcription and stress. We use repeats to characterize pathways that regulate genome maintenance.
Check out our new book on stress-induced mutagenesis and genomic instability. We are so grateful to the authors, all leaders in their respective fields, for contributing to this exciting new volume.